Concurrent Session 6: Beyond the Joint in OA: Nervous System, Gut, Heart, Brain, etc.

Comorbidities and Osteoarthritis

Date/Time: Saturday, March 18, 2023 - 5:00 PM to 6:30 PM
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Description:

Osteoarthritis (OA) is a major source of pain, disability and socio-economic costs worldwide. The epidemiology of the disorder is complex and multifactorial, with genetic, biological and biomechanical components. The coexistence of chronic diseases with osteoarthritis is also very common, especially in the last decades of life. For example, according to the Centers for Disease Control and Prevention, more than 30% of people with diabetes and heart disease have OA. It is important to separate comorbidity and multimorbidity. Clinically, comorbidities in OA create greater challenges for management. The number and profile of different comorbid conditions determine the severity and burden of the disease.

The presence of multiple comorbidities could be explained in OA by different risk factors of the disease, such as aging. Associations of osteoarthritis and gastrointestinal diseases are well documented and are generally attributed to the long-term use of analgesics, especially nonsteroidal anti-inflammatory drugs (NSAIDs). Various associations are well known as the association between gastrointestinal pathologies and osteoarthritis, probably related to the use of analgesics or NSAIDs. The relationship between cardiovascular diseases and osteoarthritis seems more complex. It is easy to understand that patientswith osteoarthritis with mobility limitations or the presence of risk factors common to both entities, such as obesity and metabolic syndrome, are more likely to have cardiovascular diseases. The link between cardiovascular pathology and progression of osteoarthritis highlights the role of inflammation in both pathologies. This should lead us to systematically research and manage the comorbidities of our osteoarthritis patients as soon as possible.

 

Abstract(s):

  • O-43
    DEEP IMMUNOPHENOTYPING OF OSTEOARTHRITIS
    PATIENTS DEMONSTRATES BASELINE ALTERATIONS
    IN MONOCYTE POPULATIONS IN OA, DENDRITIC
    CELL SUBPOPULATIONS AMONG RADIOGRAPHIC
    PROGRESSORS, AND TH17 CELLS AMONG PAIN
    PROGRESSORS    .
    E. Holmlund1, L. Schlupp2, G. Dyson2, M. Barrett2, M. Jeffries2; 1Univ. of
    Oklahoma Hlth.Sci. Ctr., Oklahoma City, OK, 2Oklahoma Med. Res. Fndn.,
    Oklahoma City, OK

    O-44
    HYPERTENSION EXACERBATES JOINT PATHOLOGY IN
    A SURGICAL MODEL OF OSTEOARTHRITIS IN A SEXDEPENDENT
    MANNER
    T. Yeater, J. L. Griffith, C. J. Cruz, F. M. Patterson, J. L. Aldrich, K. D. Allen;
    Univ. of Florida, GAINESVILLE, FL

    O-45
    THE PECULIARITIES OF INTESTINAL MICROBIOME IN
    PATIENTS WITH OSTEOARTHRITIS
    O. Gubska1, A. Kuzminets1, O. Koliada2, V. Moseyko2; 1Bogomolets Natl.
    Med. Univ., Kyiv, Ukraine, 2Molecular Genetic Lab. “Diagen”, Kyiv, Ukraine

    O-46
    THE RELATIONSHIP OF OSTEOARTHRITIS AND
    HYPERTENSION ON PAIN AND DEPRESSION
    Y. Yip, C. Wen; The Hong Kong Polytechnic Univ., Hong Kong, Hong Kong

    O-47
    ASSOCIATION BETWEEN METABOLIC SYNDROME AND
    KNEE PAIN OVER 10-13 YEARS IN MIDDLE-AGED ADULTS
    B. Eathakkattu Antony1, A. Singh1, B. Fraser1, A. Venn1, L. Blizzard1, G.
    Jones1, C. Ding1,2,3; 1Univ. of Tasmania, Hobart, Australia, 2Southern Med.
    Univ., Zhujiang, China, 3Monash Univ., Melbourne, Australia

Speaker(s):