Date/Time: Saturday, March 18, 2023 - 8:45 AM to 10:15 AM
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Abstract(s):

• O-18
  NOD2 ATTENUATES OSTEOARTHRITIS VIA
  REPROGRAMMING INFLAMMATORY RESPONSE OF
  SYNOVIAL MACROPHAGES
  C. Li, S. Lin, Z. Ouyang, S. Li, T. Liu, Y. Ding; Sun Yat-sen Mem. Hosp., Sun
  Yat-sen Univ., Guangzhou, China

  O-19
  ANTIBODY MEDIATED IL12 PATHWAY MODULATION
  HAS A DISEASE MODIFIYING EFFECT ON POSTTRAUMATIC
  OSTEOARTHRITIS IN MICE.
  P. Haubruck1, C. Blaker1, C. Hill2, Y. Liu1, E. Clarke1, C. Shu1, C. Little1;
  1Kolling Inst. / Inst. of Bone and Joint Res., St Leonards, Australia, 2Kolling
  Inst., St Leonards, Australia

  O-20
  CARTILAGE-SPECIFIC SIRT6 LOSS INCREASES SURGERYINDUCED
  AND AGE-ASSOCIATED OA IN MICE
  J. A. Collins1, C. Kim1, A. Coleman1, A. Little1, K. Kelley2, S. Chubinskaya3,
  M. Peffers4, T. Freeman1, R. Loeser2; 1Thomas Jefferson Univ., Philadelphia,
  PA, 2Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, 3Rush Med. Coll.,
  Chicago, IL, 4The Univ. of Liverpool, Liverpool, United Kingdom

  O-21
  EXCESSIVE MECHANICAL STRESS ENHANCES
  MECHANICAL STRESS SENSITIVITY OF CARTILAGE
  THROUGH THE MECHANOSENSITIVE ION CHANNEL
  PIEZO2
  S. Kawabata, T. Kojima, K. Takeshita, A. Mashimo, H. Terada, C. Takasu, N.
  Kanemura, K. Murata; Saitama Prefectural Univ., Koshigaya, Japan

  O-22
  CARTILAGE SPECIFIC TRANSFORMING GROWTH
  FACTOR BETA RECEPTOR II DELETION DRIVES
  MEDIAL COLLATERAL LIGAMENT CALCIFICATION IN
  SPONTANEOUS MOUSE OA
  J. St Amant1, J. Michaud1, L. De Guzman1, D. Hinds1, M. Coyle1, J. Trujillo
  Torres1, A. Pozzi2, A. L. Clark1; 1Univ. of Guelph, Guelph, ON, Canada,
  2Vanderbilt Univ. Med. Ctr., Nashville, TN
   

Speaker(s):

• Jessica Bertrand, Dr. rer. nat.