Concurrent Session 12: Pain: Basic Science
Immune Regulation of Osteoarthritis-Related Pain
Date/Time: Monday, March 20, 2023 - 8:45 AM to 10:15 AM
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Pain normally serves as a warning sign of inflammation and damage, that disappears when inflammation and damage resolves. However, in a substantial number of patients with inflammatory diseases pain persists even after cessation of inflammation. Similarly, in patient with osteoarthritis the extent of pain is not directly linked to the damage and pain even may persist after total knee replacement. Pain has classically has been associated with aberrations in the nervous system. Yet, over the years it has become apparent that the mechanisms that drive pain are not solely based of aberrant nerve function but also includes interactions between immune cells and neurons. In this session an overview will be provide on how immune cells interact with the nervous system. In nervous tissue immune cells communicate with sensory neurons to to help resolve pain. However, these interactiosn also can go awry and promote pain, in e.g. osteoarthritis. What is learned about this neuro-immune interactions can also be used for the development of highly needed new pain therapies that target endogenous resolution pathways.
SEX SPECIFIC REGULATION OF PAIN SENSITISERS IN
SURGICALLY INDUCED MURINE OSTEOARTHRITIS
REVEALS A MORE INFLAMMATORY PHENOTYPE IN
V. Batchelor1, J. Miotla-Zarebska1, Z. Wang2, B. Gerritsen3, N. Eijkelkamp3,
C. I. Svensson2, T. L. Vincent1; 1The Kennedy Inst. Of Rheumatology, Oxford,
United Kingdom, 2Karolinska Inst., Stockholm, Sweden, 3Ctr. for Translational
Immunology, UMC Utrecht, Utrecht, Netherlands
THE ROLE OF SILENT NOCICEPTORS IN INFLAMMATORY
T. A. Nees1,2, N. Wang2,3, P. Adamek4, C. Verkest4, C. La Porta2, I. Schäfer2,
J. Virnich4, S. Balkaya4, V. Prato2, C. Morelli5, N. Zeitzschel4, V. Begay6, Y. J.
Lee7, A. Tappe-Theodor2, G. R. Lewin6, P. A. Heppenstall5, F. J. Taberner8, S.
G. Lechner4,2; 1Heidelberg Univ. Hosp., Heidelberg, Germany, 2Heidelberg
Univ., Heidelberg, Germany, 3Cardiovascular and Cerebrovascular Hosp.
of Yan’an Univ. Affiliated Hosp., Shaanxi, China, 4Univ. Med. Ctr. Hamburg-
Eppendorf, Hamburg, Germany, 5SISSA: Scuola Internazionale Superiore di
Studi Avanzati, Trieste, Italy, 6Max Delbrück Ctr. for Molecular Med., Berlin,
Germany, 7Gachon Univ. Coll. of Med., Incheon, Korea, Republic of, 8Univ.
Miguel Hernández – CSIC, Alicante, Spain
LONGITUDINAL TRAJECTORIES OF PAIN SENSITIZATION
IN PEOPLE WITH OR AT RISK OF KNEE OSTEOARTHRITIS:
THE MULTICENTER OSTEOARTHRITIS STUDY
K. Aoyagi1,2, N. Wang3, L. Frey-Law4, C. E. Lewis5, M. Nevitt6, T. Neogi2;
1Univ. of Texas at El Paso, El Paso, TX, 2Boston Univ. Sch. of Med., Boston,
MA, 3Boston Univ. Sch. of Publ. Hlth., Boston, MA, 4Univ. of Iowa, Iowa City,
IA, 5Univ. of Alabama at Birmingham, Birmingham, AL, 6Univ. of California at
San Francisco, San Francisco, CA
MYOSTATIN AND CXCL11 PROMOTE DORSAL
ROOT GANGLIA MACROPHAGES TO MAINTAIN
C. Martin Gil1, R. Raoof2, S. Versteeg1, F. P. Lafeber1,1, S. C. Mastbergen1,1,
N. Eijkelkamp1; 1Univ. Med. Ctr. Utrecht, Utrecht, Netherlands, 2Amsterdam
Univ. Med. Ctr., Amsterdam, Netherlands
ENHANCED ACTIVATION OF THE PARABRACHIAL
NUCLEUS FOLLOWING AN ACUTE NOXIOUS STIMULUS
IS OBSERVED IN MALE AND FEMALE MICE WITH
T. A. Linstrom1, S. Gonzales-Malcolm2, C. Blaker1, K. Aubrey1, C. Little1,
S. Zaki3,1; 1Kolling Inst. of Med. Res., Faculty of Med. and Hlth., Univ.
of Sydney, St Leonards, Australia, 2Faculty of Sci., Univ. of Sydney,
Camperdown, Australia, 3Sydney Sch. of Vet. Sci., Faculty of Sci., Univ. of
Sydney, Camperdown, Australia