Date/Time: Sunday, March 19, 2023 - 2:00 PM to 3:30 PM
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Description:

Chronic inflammation is a common pathogenic feature of a heterogeneous suite of chronic inflammatory diseases that collectively represent the leading causes of disability and mortality worldwide. While tissue- and disease-specific factors shape distinct inflammatory microenvironments, seemingly unrelated diseases can respond to similar therapies. However, it has been extremely challenging to design personalized therapies given the disease heterogeneity and poorly characterized cellular and molecular components. Single-cell technologies offer an unbiased approach to characterizing disease heterogeneity. Our research goal is to fill an enormous unmet need by developing powerful AI computational methods to disentangle shared and unique pathogenic programs and pathways underlying chronic inflammatory diseases (e.g., rheumatoid arthritis, ulcerative colitis, etc) and non-inflammatory arthritis (e.g., osteoarthritis) to elucidate novel mechanisms towards personalized medicine.

Abstract(s):

• O-68
  MULTI-OMICS ANALYSES OF GUT MICROBIOME,
  HOST METABOLISM AND SYMPTOMATIC HAND
  OSTEOARTHRITIS CONDUCTED WITHIN THE XIANGYA
  OSTEOARTHRITIS STUDY
  J. Wei1,2,3, Z. Yang3, J. Li2, Y. Zhang4, W. Zhang5, M. Doherty5, T. Yang1, H.
  Li2,3, Y. Yang2,3, C. Li6, C. Zeng2,3,6, G. Lei2,3,6; 1Hlth.Management Ctr., Xiangya
  Hosp., Central South Univ., Changsha, China, 2Dept. of Orthopaedics,
  Xiangya Hosp., Central South Univ., Changsha, China, 3Hunan Key Lab.
  of Joint Degeneration and Injury, Xiangya Hosp., Central South Univ.,
  Changsha, China, 4Div. of Rheumatology, Allergy, and Immunology, Dept.
  of Med., Massachusetts Gen. Hosp., Harvard Med. Sch., Boston, MA,
  5Academic Rheumatology, Clinical Sci. Building, Univ. of Nottingham, City
  Hosp., Nottingham, United Kingdom, 6Natl. Clinical Res. Ctr. for Geriatric
  Disorders, Xiangya Hosp., Central South Univ., Changsha, China

  O-69
  CAUSAL ASSOCIATIONS OF BMI WITH OSTEOARTHRITIS
  USING BIDIRECTIONAL MENDELIAN RANDOMISATION
  A. Kamps1, J. Runhaar1, K. Trajanoska2, W. Thompson3, S. Swain4,
  W. Zhang3, E. I. de Schepper1, S. M. Bierma-Zeinstra1; 1Erasmus MC,
  Rotterdam, Netherlands, 2McGill Univ., Montreal QC, QC, Canada, 3Univ. of
  Nottingham, Nottingham, United Kingdom, 4Univ. of Oxford, Oxford, United
  Kingdom

  O-70
  LIFETIME RISK AND GENETIC PREDISPOSITION TO POSTTRAUMATIC
  OSTEOARTHRITIS OF THE KNEE: TIME-TOEVENT
  AND RELATED ANALYSES IN THE UK BIOBANK
  B. Hollis1, L. Southam2, C. Chatzigeorgiou1, K. Hatzikotoulas2, W. S. Kluzek3,
  A. Williams4, E. Zeggini5, L. Jostins-Dean1, F. E. Watt6,1; 1Univ. of Oxford,
  Oxford, United Kingdom, 2Helmholtz, Munich, Germany, 3Univ. of Nottingham,
  London, United Kingdom, 4Fortius Clinic, London, United Kingdom,
  5Helmholtz, Munich, United Kingdom, 6Imperial Coll. London, London, United
  Kingdom

  O-71
  NOVEL MECHANISMS OF MICRORNA-MEDIATED
  ANABOLIC EFFECTS IN OSTEOARTHRITIS
  M-F. Hsueh1,2, M. Orenduff1, M. P. Bolognesi2, M. E. Easley2, P. Onnerfjord3,
  V. B. Kraus1,4; 1Duke Molecular Physiology Inst., Duke Univ., Durham, NC,
  2Orthopaedic Surgery, Duke Univ. Med. Ctr., Durham, NC, 3Clinical Sci.,
  Lund Univ., Lund, Sweden, 4Div. of Rheumatology, Duke Univ. Med. Ctr.,
  Durham, NC

  O-72
  TRYPTOPHAN METABOLITES ARE ASSOCIATED WITH
  EROSION AND PAIN IN HAND OSTEOARTHRITIS:
  RESULTS FROM THE DIGICOD COHORT
  M. Binvignat1,2, P. Emond3, F. Mifsud4, B. Miao2, A. Courties1, E. Maheu1, M.
  Kloppenburg5, P. Richette4, A. J. Butte2, E. Mariotti-Ferrandiz1, F. Berenbaun1,
  H. Sokol1, J. Sellam1; 1Sorbonne Univ., Paris, France, 2UCSF, San Francisco,
  CA, 3Univ. de Tours, Tours, France, 4Univ. Paris Cite, Paris, France, 5Leiden
  Univ., Leiden, Netherlands

Speaker(s):

• Fan Zhang, PhD